HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanamide → {4-Amino-2-[4-(4-cyclopropylmethyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-fluoro-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanamide | HCID 9864 | — |
| Reactant | 3-Fluorophenacyl bromide | HCID 2737451 | — |
| Reactant | 1-(4-Isothiocyanatophenyl)-4-cyclopropylmethylpiperazine | HCID 21958916 | — |
| Product | {4-Amino-2-[4-(4-cyclopropylmethyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-fluoro-phenyl)-methanone | HCID 10297718 | — |
Reaction Steps
This compound was prepared from cyanamide, 1-(4-isothiocyanatphenyl)-4-cyclopropylmethylpiperazine (of Example 14G) and 2-bromo-1-(3-fluoro-phenyl)ethanone (Aldrich) following the procedure used in Example 24 Mass spectrum (ES) MH+=452.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07105670B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-20e8f9d923b54157b0a435dd73c491a3 |
| Source note | uspto-grants-2006_09 |