Dimethylamine → N-(3-(2-(Dimethylamino)-1-hydroxyethyl)phenyl)-2',4'-difluorobiphenyl-4-sulfonamide

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Reaction Steps

Using a method analogous to Method D, using 2′,4′-difluoro-N-(3-(oxiran-2-yl)phenyl)biphenyl-4-sulfonamide and 33% dimethylamine in ethanol, a mixture of regioisomers was obtained. Reverse-phase HPLC was used to purify the mixture and the title compound was obtained as a pale orange powder. 1H NMR (300 MHz, CDCl3): δ 2.70 (6H, s), 3.05-3.10 (2H, m), 5.05 (1H, bd), 6.80-6.95 (2H, m), 7.00-7.22 (3H, m), 7.25-7.35 (2H, m), 7.49 (2H, d, J=8 Hz) and 7.87 (2H, d, J=8 Hz).

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