Morpholine → 2',4'-Difluoro-N-(3-(1-hydroxy-2-morpholinoethyl)phenyl)biphenyl-4-sulfonamide

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Reaction Steps

Using a method analogous to Method D, using 2′,4′-difluoro-N-(3-(oxiran-2-yl)phenyl)biphenyl-4-sulfonamide and 1 M morpholine in methanol, a mixture of regioisomers was obtained. Reverse-phase HPLC was used to purify the mixture and the title compound was obtained as a pale orange powder. 1H NMR (300 MHz, CDCl3): δ 2.20-2.40 (3H, m), 2.50-2.70 (2H, m), 3.60-3.80 (4H, m), 4.66 (1H, m), 6.85-7.00 (2H, m), 7.03-7.19 (3H, m), 7.20-7.30 (1H, m), 7.30-7.40 (1H, m), 7.57 (2H, d, J=8 Hz) and 7.91 (2H, d, J=8 Hz). MS, m/z: Calcd, 474.142. Found, 474.56 (M).

Provenance & Evidence