Methylamine → 2',4'-Difluoro-N-(3-(2-hydroxy-1-(methylamino)ethyl)phenyl)biphenyl-4-sulfonamide

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Reaction Steps

Using a method analogous to Method D, using 2′,4′-difluoro-N-(3-(oxiran-2-yl)phenyl)biphenyl-4-sulfonamide and 33% methylamine in ethanol, the title compound was obtained as a light orange powder (165 mg) by flash chromatography of mixture of regioisomers which gave ABD783. 1H NMR (400 MHz, CDCl3): δ 2.10 (3H, s), 3.51 (1H, m), 3.60-3.62 (2H, m), 5.10 (3H, br s), 6.70-6.95 (3H, m), 7.10-7.15 (4H, m), 7.20-7.25 (1H, m), 7.34 (2H, d, J=8 Hz) and 7.73 (2H, d, J=8 Hz). MS, m/z: Calcd, 418.11. Found, 418.09 (M).

Provenance & Evidence