Dimethylamine → N-(3-(1-(Dimethylamino)-2-hydroxyethyl)phenyl)-2',4'-difluorobiphenyl-4-sulfonamide

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Reaction Steps

Using a method analogous to Method D, using 2′,4′-difluoro-N-(3-(oxiran-2-yl)phenyl)biphenyl-4-sulfonamide and 33% dimethylamine in ethanol, a mixture of regioisomers was obtained. Reverse-phase HPLC was used to purify the mixture and the title compound was obtained as a pale orange powder from the mixture of isomers as gave ABD784. 1H NMR (300 MHz, CDCl3): δ 2.08 (6H, s), 3.40 (3H, m), 3.48 (1H, m), 3.62-3.64 (1H, m), 6.87-6.96 (3H, m), 7.04-7.12 (2H, m), 7.20-7.25 (1H, m), 7.33-7.40 (1H, m), 7.53 (2H, d, J=8 Hz) and 7.78 (2H, d, J=8 Hz). MS, m/z: Calcd, 432.132. Found, 432.56 (M).

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