HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-(3-Nitrophenyl)-2-oxoethyl acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Bromo-1-(3-nitrophenyl)ethan-1-one | HCID 75213 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 2-(3-Nitrophenyl)-2-oxoethyl acetate | HCID 13173800 | 87.5% |
Reaction Steps
2-Bromo-1-(3-nitrophenyl)ethanone (25 g) was dissolved in methylethyl ketone (150 mL). NaOAc (12.5 g) was added and the mixture stirred for 48 hours. Water (100 mL) was added and the reaction mixture extracted with DCM. The DCM layer was dried over Na2SO4 and concentrated to give the title compound (20 g, 87%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08207167B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-125495b67b2042a49067997dd3748cf8 |
| Source note | uspto-grants-2012_06 |