反应详情

温度

0 °C

2-(3-Nitrophenyl)-2-oxoethyl acetate (20 g) was dissolved in MeOH (200 mL) and cooled to 0° C. Sodium borohydride (6.78 g) was added pinch-wise to the reaction mixture and this was stirred for 2 hours at room temperature. The reaction was quenched by addition of acetone (10 mL) and the mixture concentrated to give a solid. The solid was treated with water (100 mL) and extracted with ethyl acetate (3×100 mL). The crude title compound obtained was used for next step without further purification (18 g, 89%).

1. customThe reaction was quenched by addition of acetone (10 mL)
2. concentrationthe mixture concentrated
3. customto give a solid
4. extractionextracted with ethyl acetate (3×100 mL)