反应详情

温度

70 °C

1-(3-(Benzyloxycarbonylamino)phenyl)-2-(tert-butyldimethylsilyloxy)ethyl methanesulfonate (3.5 g) was dissolved in dry THF (10 mL) and methoxyethylamine (5.4 g) was added in a sealed tube and heated to 70° C. for 16 hours. Water was added and the reaction mixture extracted with DCM (2×20 mL). The organic phase was separated, dried over Na2SO4 and concentrated to give the crude product, which was purified by column chromatography to give the title compound (1 g, 30%).

1. extractionthe reaction mixture extracted with DCM (2×20 mL)
2. customThe organic phase was separated
3. dry with materialdried over Na2SO4
4. concentrationconcentrated
5. customto give the crude product, which
6. customwas purified by column chromatography