HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R,R)-Hydrobenzoin → Piragliatin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R,R)-Hydrobenzoin | HCID 853019 | — |
| Reactant | 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-((S)-3-oxo-cyclopentyl)-N-pyrazin-2-yl-propionamide | HCID 58697917 | — |
| Product | Piragliatin | HCID 10432339 | — |
Reaction Steps
2(R)-(3-Chloro-4-methanesulfonyl-phenyl)-3-((R)-3-oxo-cyclopentyl)-N-pyrazin-2-yl-propionamide was prepared in a similar manner as 2(R)-(3-chloro-4-methanesulfonyl-phenyl)-3-((S)-3-oxo-cyclopentyl)-N-pyrazin-2-yl-propionamide (Example 47) starting with (R,R)-hydrobenzoin (Wang, Z.-M.; Sharpless, K. B. J. Org. Chem. 1994, 59, 8302).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07105671B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-755a626dcbab49f0a6e7f48cf6193603 |
| Source note | uspto-grants-2006_09 |