Nitroindoline → 2,3-dihydro-1H-indol-1-amine

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Reaction Steps

Substituted indolines are prepared such as by the procedures described in Scheme 18. Substituted amino-indolines 68 are prepared from the nitroindoline 66 and a ketone in the presence of NaHB(OAc)3 to form the 1-substituted indoline 67. The nitroindoline 67 is hydrogenated, such as with H2 in the presence of a catalyst, such as Pd/C, to yield the amino-indoline 68.

Provenance & Evidence