Potassium Nitrate → 3,3-Dimethyl-6-nitro-2,3-dihydro-benzo[d]isothiazole 1,1-dioxide

HRID 2214184Notes

Reaction equation

HRID 2214184 reaction equation
[CH3:1][C:2]1([CH3:13])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[S:4](=[O:12])(=[O:11])[NH:3]1.[N+:14]([O-])([O-:16])=[O:15].[K+]>OS(O)(=O)=O>[CH3:1][C:2]1([CH3:13])[C:6]2[CH:7]=[CH:8][C:9]([N+:14]([O-:16])=[O:15])=[CH:10][C:5]=2[S:4](=[O:12])(=[O:11])[NH:3]1

Participants

4

Reactant 2

HCID 24434Potassium NitrateHCID 44473552,3-Dihydro-3,3-dimethyl-1,2-benzisothiazole 1,1-dioxide

Product 1

HCID 222493723,3-Dimethyl-6-nitro-2,3-dihydro-benzo[d]isothiazole 1,1-dioxide

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Conditions

Temperature
0 °C

Procedure

3,3-Dimethyl-2,3-dihydro-benzo[d]isothiazole 1,1-dioxide was added to KNO3 in H2SO4 cooled to 0° C. and stirred for 15 min. The reaction was warmed to RT and stirred overnight. The mix was poured into ice and extracted with EtOAc (3×), washed with H2O and brine, dried and evaporated to give the product which was used without further purification.

Workup

  1. temperatureThe reaction was warmed to RT
  2. stirringstirred overnight
  3. additionThe mix was poured into ice
  4. extractionextracted with EtOAc (3×)
  5. washwashed with H2O and brine
  6. customdried
  7. customevaporated
  8. customto give the product which
  9. customwas used without further purification

Sources & evidence

ORD record
ord-9e2151b17e26418a823d5f2c1917ca1d
Source dataset
uspto-grants-2006_09
Patent number
US07105682B2

Reaction notes

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