HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Nitroindole → 3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-nitro-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Nitroindole | HCID 22523 | — |
| Reactant | 1-Methyl-4-piperidone | HCID 74049 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-nitro-1H-indole | HCID 11334373 | — |
Reaction Steps
5-Nitroindole (2.6 g) was dissolved in 100 mL anhydrous MeOH, followed by 5 g N-methyl-4-piperidone and NaOMe (5 g) powder. The mixture was heated to reflux under N2 overnight. The mixture was concentrated in vacuo, and was extracted between saturated NaHCO3 solution and EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07105682B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-e465d17012a9480aa1edcd3e0cf09913 |
| Source note | uspto-grants-2006_09 |