Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 4-Phenylpiperidine-4-carbonitrile hydrochloride | HCID 3084973 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Phenylpiperidine | HCID 69873 | — |
Reaction Steps
4-Cyano-4-phenylpiperidine hydrochloride (10.0 g, 45.0 mmol) was combined with KOH pellets and stirred vigorously under Ar at 160° C. for 4 h. The reaction mix was cooled to RT and dissolved into toluene (100 ml) and H2O (100 ml). After separation of the layers, the aqueous layer was back-extracted two times with toluene. The combined organic layer was dried over Na2SO4, concentrated in vacuo, and dried under high vacuum, yielding a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07105682B2 |
|---|
| Source dataset | uspto-grants-2006_09 |
|---|
| ORD ID | ord-15291cc691014c999d6cd4e4906bc3c3 |
|---|
| Source note | uspto-grants-2006_09 |
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