反应详情

A solution of the compound of example 52 (700 mg, 1.59 mmol) in ethanol (95%, 100 mL) was hydrogenated in the presence of a catalytic amount palladium (10% on charcoal). After 24 h of stirring, the reaction was complete. The mixture was filtered over a celite pad and the solvent was evaporated. The residue was distributed between ethyl acetate and water. The aqueous phase was extracted twice more with ethyl acetate. The recombined organic layer was washed with brine, dried over sodium sulfate, filtered, and evaporated.

1. filtrationThe mixture was filtered over a celite pad
2. customthe solvent was evaporated
3. extractionThe aqueous phase was extracted twice more with ethyl acetate
4. washThe recombined organic layer was washed with brine
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. customevaporated