Lithium hydroxide, monohydrate → HCID 87734401, compound

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Reaction Steps

The compound of Example 165 (200 mg, 0.54 mmol) was dissolved in a mixture of THF(10 mL) and water (2 mL). Lithium hydroxide monohydrate (46 mg, 1.07 mmol) was added and the mixture was stirred for 24 h at room temperature. The solvent was evaporated and the residue was dissolved in water (5 mL) and extracted with ether. The water phase was acidified by HCl to pH1 and extracted with ethyl acetate. After drying over sodium sulfate, filtration and evaporation, the solvent was evaporated to dryness. 1H NMR(CDCl3, 300 MHz): 1.43(s, 18H); 3.10(s, 4H).

Provenance & Evidence