Formic Acid → 3-Carboxy-pentanedioic acid di-tert-butyl ester

Participants

Reaction Conditions

Reaction Steps

The compound of Example 166 (170 mg, 0.512 mmol) was dissolved in ethyl acetate. Formic acid (61 μL, 1.53 mmol) was added and the mixture was heated at 80° C. for 3 h. After cooling to room temperature, the reaction mixture was extracted three times with water, dried (sodium sulfate), filtered and evaporated to dryness. 1H NMR(CDCl3, 300 MHz): 1.43(s, 18H); 2.50, 2.65(2dd, J1=16.7 Hz, J2=6.2 Hz, 4H); 3.20(p, J=6.2 Hz, 1H).

Provenance & Evidence