Hydrochloric Acid → (R)-7-[3-amino-4-(2,4,5-trifluoro-phenyl)-butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid (2-methanesulfonyl-ethyl)-amide hydrochloride

Participants

Reaction Steps

(R)-[3-[1-(2-Methanesulfonyl-ethylcarbamoyl)-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl]-3-oxo-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester 2b (0.06 g, 0.091 mmol) was dissolved in a little ethyl acetate. A solution of 3.1 N hydrochloric acid in 4 mL of ethyl acetate was then added to the solution. The reaction mixture was reacted at room temperature for 4 hours until thin lay chromatography showed the starting material disappeared, and was concentrated under reduced pressure to obtain the title compound (R)-7-[3-amino-4-(2,4,5-trifluoro-phenyl)-butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid (2-methanesulfonyl-ethyl)-amide hydrochloride 2 (60 mg) as a white solid.

Provenance & Evidence