Hydrogen Bromide → HCID 69111032, compound

Participants

Reaction Steps

Into a 1 L four-necked flask equipped with a condenser tube, 28.55 g of (R)-(−)-1-(4-methoxyphenyl)-2-phenylpropane, 570 mL of acetic acid and 59 mL of 48% hydrobromic acid were charged, and a reaction was carried out at 110° C. for 7 hours. After cooling, acetic acid was distilled off under reduced pressure, and 100 mL of water and 140 mL of toluene were added thereto. The organic phase was separated, the aqueous phase was extracted with toluene, the toluene layer and the organic phase were put together, the solvent was distilled off under reduced pressure, and the obtained crystals were recrystallized from methanol to obtain 26.65 g of (R)-(−)-1-(4-hydroxyphenyl)-2-phenylpropane [H-Ph-CH(CH3)—CH2-Ph-OH] (yield: 99.5%).

Provenance & Evidence