HCID 69110726, compound → HCID 69337696, compound

HRID 2214330Notes

Reaction equation

HRID 2214330 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9](=O)[C@H:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH3:11])[CH:5]=[C:6]([F:8])[CH:7]=1.ClC1C=CC(C(=O)[C@H](C2C=CC=CC=2)C)=CC=1>>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C@H:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH3:11])[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

3

Reactant 2

HCID 69110726HCID 69110726, compoundHCID 69337115HCID 69337115, compound

Product 1

HCID 69337696HCID 69337696, compoundYield 87.3%

Procedure

A reaction was carried out in the same manner as in first step of Example 4-1 except that 31.0 g (126 mmol) of (S)-1-(3,5-difluorophenyl)-2-phenylpropane-1-one [H-Ph-CH(CH3)—CO-PhFF-H] prepared in first step was employed instead of (S)-1-(4-chlorophenyl)-2-phenylpropane-1-one [H-Ph-CH(CH3)—CO-Ph-Cl] in second step of Example 4-1 to obtain 25.4 g (110 mmol) of (R)-1-(3,5-difluorophenyl)-2-phenylpropane [H-Ph-CH(CH3)—CH2-PhFF-H] (yield: 87%)

Workup

  1. customprepared in first step

Sources & evidence

ORD record
ord-bd0406cf56444b0db3ec8a8ad8a1039a
Source dataset
uspto-grants-2006_09
Patent number
US07108895B2

Reaction notes

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