1-Bromo-4-(pentafluoro-lambda6-sulfanyl)benzene → HCID 86591924, compound

Participants

Reaction Steps

A reaction was carried out in the same manner as in second step of Example 4-3 except that 3.08 g (10.9 mmol) of 4-bromophenyl sulfur pentafluoride [Br-Ph-SF5] was employed instead of 1-bromo-3,5-difluorobenzene in second step of Example 4-3 and 3.00 g (10.9 mmol) of (R)-2,6-difluoro-4-(2-phenylpropyl)phenylboric acid [H-Ph-CH(CH3)—CH2-PhFF-B(OH)2] obtained in third step of Example 4-5 was employed instead of (R)-4-(2-phenylpropyl)phenylboric acid [H-Ph-CH(CH3)—CH2-Ph-B(OH)2] to obtain 2.03 g (4.67 mmol) of (R)-4-(2,6-difluoro-4-(2-phenylpropyl)phenyl)phenyl sulfur pentafluoride [H-Ph-CH(CH3)—CH2-PhFF-Ph-SF5] (yield: 43%). MS m/e: 434(M+)

Provenance & Evidence