1,4-Dioxane hydrochloride → HCID 21054030, compound

Participants

Reaction Steps

Boc protected amine 28 (243 mg) in dioxane (1 mL) was treated with a 4.0N HCl/dioxane solution (2 mL) and stirred for 2 hours at room temperature. The mixture was concentrated in vacuo, slurried in CH2Cl2 and evaporated in vacuo to give 208 mg (100%) of desired 2-(2-amino-3,3-dimethyl-butyryl)-6,10-dithia-2-aza-spiro[4.5]decane-3-carboxylic acid methyl ester 29 as a white solid and as the HCl salt. Mass Spec. MH+=347.1.

Provenance & Evidence