Ammonia → HCID 21947624, compound

HRID 2214435Notes

Reaction equation

HRID 2214435 reaction equation
O[C:2]1[C:3](=[O:22])[N:4]([CH2:11][C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14][CH:13]=2)[N:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[NH3:23]>>[NH2:23][C:2]1[C:3](=[O:22])[N:4]([CH2:11][C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14][CH:13]=2)[N:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 178516905HCID 178516905, compound

Product 1

HCID 21947624HCID 21947624, compound

Conditions

Temperature
130 °C

Procedure

9.4 g (31.6 mmol) of 4-hydroxy-2-naphthalen-1-ylmethyl-5-nitro-2H-pyridazin-3-one were combined with 150 ml saturated methanolic ammonia solution and heated to 130° C. for 24 hours in a Roth bomb. The mixture was concentrated down to a volume of about 40 ml using the rotary evaporator, the product precipitated was suction filtered and recrystallised from tetrahydrofuran.

Workup

  1. concentrationThe mixture was concentrated down to a volume of about 40 ml
  2. customthe rotary evaporator
  3. customthe product precipitated
  4. filtrationfiltered
  5. customrecrystallised from tetrahydrofuran

Sources & evidence

ORD record
ord-f515d3f695484ed78613e6d9da73b069
Source dataset
uspto-grants-2006_09
Patent number
US07109192B2

Reaction notes

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