Potassium Carbonate → HCID 21947691, compound

Participants

Reaction Steps

A solution of 900 mg (2.79 mmol) of 2-methylsulphanyl-5-(naphthalen-1-ylmethyl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one (Example 1f) in 15 ml of dimethylformamide was combined with 415 mg (3.0 mmol) of potassium carbonate and 399 mg (3.0 mmol) of 1-bromo-2-butyne and stirred at ambient temperature for eight hours. Then the mixture was diluted with approx. 30 ml of water and saturated with sodium chloride, whereupon the reaction product crystallised out. It was suction filtered and purified by column chromatography (silica gel, eluant:petroleum ether with 10–50% ethyl acetate).

Provenance & Evidence