Acetic Acid → HCID 21947680, compound

Participants

Reaction Steps

A solution of 500 mg of potassium permanganate in 20 ml of water was added dropwise to a solution of 600 mg (1.60 mmol) of 3-(but-2-ynyl)-2-methylsulphanyl-5-(naphthalen-1-ylmethyl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one in 30 ml glacial acetic acid, with stirring, at ambient temperature. After three hours at ambient temperature a sodium hydrogen sulphite solution was added dropwise until the reaction mixture was virtually decolourised again. Then it was diluted with approx. 50 ml of water and saturated with sodium chloride. The crude product precipitated was suction filtered and purified by column chromatography (aluminium oxide; eluant:dichloromethane).

Provenance & Evidence