Ammonia → 2-Chloro-3-nitropyridin-4-amine

HRID 2214442Notes

Reaction equation

HRID 2214442 reaction equation
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[NH3:12]>>[NH2:12][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[C:7]=1[N+:8]([O-:10])=[O:9]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 105357732,4-Dichloro-3-nitropyridine

Product 1

HCID 109650142-Chloro-3-nitropyridin-4-amineYield 71%

Procedure

A solution of 28.0 g (0.193 mol) of 2,4-dichloro-3-nitropyridine in 300 ml of ammonia-saturated ethanol was stirred for four days at ambient temperature, then evaporated to dryness and the crude product thus obtained was purified by column chromatography (silica gel, eluant:dichloromethane with 0–5% ethanol).

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-4584b2e026984391b118ec374951b8fe
Source dataset
uspto-grants-2006_09
Patent number
US07109192B2

Reaction notes

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