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HRID2214499

反应详情

EQUATION

反应方程式

HRID 2214499 的结构方程式

REACTANTS

反应物

4
结构：C=O
HCID712

Formaldehyde

CH2O

结构：NCCc1ccc(Cl)cc1
HCID67430

4-Chlorophenethylamine

C8H10ClN

结构：CN1CC(C(=O)N(C)Cc2ccc(F)cc2)=C(O)C1=O
HCID54698182

未命名化合物

结构：COC(=O)C(O)=CC(=O)N(C)Cc1ccc(F)cc1
HCID69655679

未命名化合物

PRODUCTS

生成物

1
结构：CN(Cc1ccc(F)cc1)C(=O)C1=C(O)C(=O)N(CCc2ccc(Cl)cc2)C1
HCID54698183

未命名化合物

PROCEDURE

实验过程

3-[(4-Fluoro-benzyl)-methyl-carbamoyl]-2-hydroxy-acrylic acid methyl ester (Compound 1-D) was treated with paraformaldehyde and 2-(4-chlorophenyl)-ethylamine as described in the preparation of Compound 1. HRMS (M−H) calcd for C21H19ClFN2O3; 401.1068. found: 401.1080. 1H NMR (500 MHz, CDCl3)δ: 2.90 (t, 2, j=7), 2.95 (s, 3), 3.72 (t, 2, J=7), 3.95 (s, 2), 4.57 (s, 2), 7.03–7.26 (overlapping m, 8). 13C NMR (125 MHz, CDCl3) δ: 33.92, 34.45, 44.42, 49.37, 51.46, 108.49, 118.91, 128.87, 129.22, 129.98, 131.99, 132.67, 136.60, 154.21, 161.42, 163.37, 164.51, 166.31.