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HRID2214500

反应详情

EQUATION

反应方程式

HRID 2214500 的结构方程式

REACTANTS

反应物

4
结构：C=O
HCID712

Formaldehyde

CH2O

结构：NCCc1ccccc1Cl
HCID83117

2-Chloro-2-phenethylamine

C8H10ClN

结构：CN1CC(C(=O)N(C)Cc2ccc(F)cc2)=C(O)C1=O
HCID54698182

未命名化合物

结构：COC(=O)C(O)=CC(=O)N(C)Cc1ccc(F)cc1
HCID69655679

未命名化合物

PRODUCTS

生成物

1
结构：CN(Cc1ccc(F)cc1)C(=O)C1=C(O)C(=O)N(CCc2ccccc2Cl)C1
HCID54698184

未命名化合物

PROCEDURE

实验过程

3-[(4-Fluoro-benzyl)-methyl-carbamoyl]-2-hydroxy-acrylic acid methyl ester (Compound 1-D) was treated with paraformaldehyde and 2-(2-chlorophenyl)-ethylamine as described in the preparation of Compound 1. HRMS (M+H) calcd for C21H21ClFN2O3: 403.1225. found: 403.1237. 1H NMR (500 MHz, CDCl3) δ: 2.96 (s, 3), 3.05 (t, 2, J=7), 3.75 (t, 2, J=7), 3.99 (s, 2), 4.58 (s, 2), 7.01–7.34 (overlapping m, 8). 13C NMR (125 MHz, CDCl3) δ: 32.37, 34.52, 42.90, 49.36, 51.47, 109.38, 115.66, 115.83, 127.18, 128.37, 129.26, 129.32, 129.67, 130.92, 132.13, 132.15, 134.01, 135.79, 152.71, 161.37, 163.33, 164.91, 166.11.