huagongshe.com
HRID2214501

反应详情

EQUATION

反应方程式

HRID 2214501 的结构方程式

REACTANTS

反应物

4
结构：C=O
HCID712

Formaldehyde

CH2O

结构：NCCc1cccs1
HCID116521

2-(Thiophen-2-yl)ethan-1-amine

C6H9NS

结构：CN1CC(C(=O)N(C)Cc2ccc(F)cc2)=C(O)C1=O
HCID54698182

未命名化合物

结构：COC(=O)C(O)=CC(=O)N(C)Cc1ccc(F)cc1
HCID69655679

未命名化合物

PRODUCTS

生成物

1
结构：CN(Cc1ccc(F)cc1)C(=O)C1=C(O)C(=O)N(CCc2cccs2)C1
HCID54698185

未命名化合物

PROCEDURE

实验过程

3-[(4-Fluoro-benzyl)-methyl-carbamoyl]-2-hydroxy-acrylic acid methyl ester (Compound 1-D) was treated with paraformaldehyde and 2-thiophen-2-yl-ethylamine as described in the preparation of Compound 1. HRMS (M−H) calcd for C19H18FN2O3S: 373.1022. found: 373.1029. 1H NMR (500 MHz, CDCl3) δ: 2.95 (s, 3), 3.14 (t, 2, J=7), 3.76 (t, 2, J=7), 3.97 (s, 2), 4.57 (s, 2), 6.81–7.21 (overlapping m, 7). 13C NMR (125 MHz, CDCl3) δ: 28.76, 34.49, 44.93, 49.46, 51.47, 109.48, 115.65, 115.82, 124.20, 125.59, 127.15, 129.28, 129.34, 132.12, 132.14, 140.34, 152.72, 161.37, 163.33, 164.94, 166.11.