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HRID2214508

反应详情

EQUATION

反应方程式

HRID 2214508 的结构方程式

REACTANTS

反应物

4
结构：C=O
HCID712

Formaldehyde

CH2O

结构：CC(C)N
HCID6363

Isopropylamine

C3H9N

结构：CN1CC(C(=O)N(C)Cc2ccc(F)cc2)=C(O)C1=O
HCID54698182

未命名化合物

结构：COC(=O)C(O)=CC(=O)N(C)Cc1ccc(F)cc1
HCID69655679

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)N1CC(C(=O)N(C)Cc2ccc(F)cc2)=C(O)C1=O
HCID54698192

未命名化合物

PROCEDURE

实验过程

3-[(4-Fluoro-benzyl)-methyl-carbamoyl]-2-hydroxy-acrylic acid methyl ester (compound 1-D) was treated with paraformaldehyde and isopropylamine as described in the preparation of Compound 1. 1H NMR (500 MHz, CDCl3) δ: 1.23 (d, 6, J=7), 3.02 (s, 3), 4.10 (s, 2), 4.45 (heptet, 1, J=7), 4.62 (s, 2), 7.03 (m, 2), 7.24 (m, 2). 13C NMR (125 MHz, CDCl3) δ: 20.61, 34.72, 44.09, 44.34, 110.21, 115.57, 115.75, 129.43, 129.50, 132.28, 132.30, 149.92, 161.35, 163.31, 164.76, 165.80.