HCID 73855564, compound → HCID 72395081, compound

HRID 2214560Notes

Reaction equation

HRID 2214560 reaction equation
[F:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[CH2:4][N:5]([O:17][CH3:18])[C:6](=[O:16])[CH:7]=[C:8]1[C:12](=[O:13])[O:11][C:10](C)(C)[O:9]1>CO>[CH3:10][O:11][C:12](=[O:13])[C:8]([OH:9])=[CH:7][C:6](=[O:16])[N:5]([CH2:4][C:3]1[CH:19]=[CH:20][CH:21]=[CH:22][C:2]=1[F:1])[O:17][CH3:18]

Participants

3

Reactant 1

HCID 73855564HCID 73855564, compound

Product 1

HCID 72395081HCID 72395081, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-(2-Fluorobenzyl)-2-(2,2-dimethyl-5-oxo-[1,3]-dioxolan-4-ylidene)-N-methoxy-acetamide was treated with methanol as described in the preparation of Compound 44-D and gave the title ester as a white syrup (59% yield). 1HNMR 400 MHz (CDCl3) δ (ppm): 3.73 (3H, s, OCH3), 3.89 (3H, s, OCH3), 4.93 (2H, s, NCH2), 6.47 (1H, s, CH), 7.05–7.36 (4H, m, aromatics). Anal. calcd for C13H14FNO5: C, 55.12; H, 4.98; N, 4.94. Found: C, 54.91; H, 5.23; N, 4.86.

Workup

  1. customas described in the preparation of Compound 44-D

Sources & evidence

ORD record
ord-3bae85f38e14449c8d59bbbe5390efcf
Source dataset
uspto-grants-2006_09
Patent number
US07109186B2

Reaction notes

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