HCID 73855558, compound → HCID 72646461, compound

HRID 2214568Notes

Reaction equation

HRID 2214568 reaction equation
C[C:2]1(C)[O:6][C:5](=[CH:7][C:8]([N:10]([CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[O:11][CH3:12])=[O:9])[C:4](=[O:22])[O:3]1>CO>[CH3:2][O:3][C:4](=[O:22])[C:5]([OH:6])=[CH:7][C:8](=[O:9])[N:10]([CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][C:18]([F:21])=[CH:19][CH:20]=1)[O:11][CH3:12]

Participants

3

Reactant 1

HCID 73855558HCID 73855558, compound

Product 1

HCID 72646461HCID 72646461, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(2,2-Dimethyl-5-oxo-[1,3]-dioxolan-4-ylidene)-N-[2-(4-fluorophenyl)-ethyl]-N-methoxy-acetamide was treated with methanol as described in the preparation Compound 44-D and gave the title ester as a clear oil (66% yield). HRMS (MAB N2) calculated for C14H16FNO5: [M]+: 297.101251. found: 297.101514. 1HNMR 400 MHz (CDCl3) δ (ppm): 2.95 (2H, t, J=7.6 Hz, CH2), 3.73 (3H, s, OCH3), 3.89 (2H, t, J=7.6 Hz, CH2), 3.92 (3H, s, OCH3), 6.44 (1H, s, CH), 7.0 (2H, m, aromatics), 7.19 (2H, m, aromatics).

Sources & evidence

ORD record
ord-8c1c86ecb0034db49f8ead572fd276e4
Source dataset
uspto-grants-2006_09
Patent number
US07109186B2

Reaction notes

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