1-Piperonylpiperazine → HCID 54704602, compound

HRID 2214649Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][C:25]=1[Cl:26])[CH2:5][N:6]([CH3:22])[C:7]([C:9]1[CH2:10][N:11]([CH2:16][CH:17](OC)OC)[C:12](=[O:15])[C:13]=1[OH:14])=[O:8].[O:27]1[C:31]2[CH:32]=[CH:33][C:34]([CH2:36][N:37]3[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]3)=[CH:35][C:30]=2[O:29][CH2:28]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][C:25]=1[Cl:26])[CH2:5][N:6]([CH3:22])[C:7]([C:9]1[CH2:10][N:11]([CH2:16][CH2:17][N:40]2[CH2:41][CH2:42][N:37]([CH2:36][C:34]3[CH:33]=[CH:32][C:31]4[O:27][CH2:28][O:29][C:30]=4[CH:35]=3)[CH2:38][CH2:39]2)[C:12](=[O:15])[C:13]=1[OH:14])=[O:8]

Participants

Reactant 2

HCID 944261-Piperonylpiperazine

HCID 54704627HCID 54704627, compound

Product 1

HCID 54704602HCID 54704602, compound

Procedure

Compound 749 was prepared from 1-(2,2-dimethoxy-ethyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid (3,4-dichloro-benzyl)-methyl-amide and 1-benzo[1,3]dioxol-5-ylmethyl-piperazine using the method described for compound 747. The title compound was isolated as a white solid (0.0068 g, 17% yield). HRMS (M+H) calcd for C27H31N4Cl2O5: 561.16716. found: 561.1674.

Sources & evidence

ORD record: ord-5bb5a4e02fc3444bab72e4a85a5b8f46
Source dataset: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07109186B2

Reaction notes

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