3,5-Dimethylisoxazole-4-sulfonamide → HCID 54704631, compound

HRID 2214655Notes

Reaction equation

HRID 2214655 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][C:25]=1[Cl:26])[CH2:5][N:6]([CH3:22])[C:7]([C:9]1[CH2:13][N:12]([CH2:14][CH2:15][CH2:16][C:17](O)=[O:18])[C:11](=[O:20])[C:10]=1[OH:21])=[O:8].[CH3:27][C:28]1[C:32]([S:33]([NH2:36])(=[O:35])=[O:34])=[C:31]([CH3:37])[O:30][N:29]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][C:25]=1[Cl:26])[CH2:5][N:6]([CH3:22])[C:7]([C:9]1[CH2:13][N:12]([CH2:14][CH2:15][CH2:16][C:17]([NH:36][S:33]([C:32]2[C:28]([CH3:27])=[N:29][O:30][C:31]=2[CH3:37])(=[O:34])=[O:35])=[O:18])[C:11](=[O:20])[C:10]=1[OH:21])=[O:8]

Participants

3

Reactant 2

HCID 49623033,5-Dimethylisoxazole-4-sulfonamideHCID 54691713HCID 54691713, compound

Product 1

HCID 54704631HCID 54704631, compound

Procedure

Compound 756 was prepared from 4-{4-[(3,4-dichloro-benzyl)-methyl-carbamoyl]-3-hydroxy-2-oxo-2,5-dihydro-pyrrol-1-yl}-butyric acid and 3,5-dimethyl-isoxazole-4-sulfonic acid amide using the method described for compound 751. The title compound was purified by preparative HPLC (C18, ODS-A, S-75 μm, 40% acetonitrile/water/0.5% TFA) and isolated as a white powder (0.0296 g, 21% yield). HRMS (M−H) calcd for C22H23N4Cl2O7S: 557.06645. found: 557.0663.

Workup

  1. customThe title compound was purified by preparative HPLC (C18, ODS-A, S-75 μm, 40% acetonitrile/water/0.5% TFA)

Sources & evidence

ORD record
ord-8ed2823fef984ae4af4bc35324b75e2f
Source dataset
uspto-grants-2006_09
Patent number
US07109186B2

Reaction notes

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