HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178454509, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3-Pyridinylboronic acid | HCID 2734378 | — |
| Reactant | HCID 178449913 | HCID 178449913 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178454509 | HCID 178454509 | — |
Reaction Steps
Pd(PPh3)4 (30 mg) was added to a degassed solution of N-(5-bromo-1H-pyrazolo[3,4-b]pyridin-3-yl-butyramide (Description 6; 150 mg, 0.5 mmol), 3-pyridyl boronic acid (95 mg, 0.8 mmmol), aq. Na2CO3 (0.75 ml, 2M) in ethanol (0.75 ml) and DMF (1.5 ml). The mixture was stirred at reflux for 12 hours, cooled and then water was added. The resulting solids were filtered and purified by column chromatography (5% MeOH/CHCl3) affording the title compound as a powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07109199B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-f9d3d1d7277f4c189c14b2b2043c4e83 |
| Source note | uspto-grants-2006_09 |