反应详情

Butyryl chloride (2.1 ml, 20.7 mmol) was added to a stirred solution of 5-bromo-1H-pyrazolo[3,4-b]pyridin-3-ylamine (4.0 g, 18.8 mmol) in pyridine (50 ml). The solution was heated at reflux for 12 hours then concentrated in vacuo. Addition of water afforded a solid which was filtered and dried to afford the title compound.

1. temperatureThe solution was heated
2. temperatureat reflux for 12 hours
3. concentrationthen concentrated in vacuo
4. additionAddition of water
5. customafforded a solid which
6. filtrationwas filtered
7. customdried