Pyridine → HCID 178449913, compound

HRID 2214742Notes

Reaction equation

HRID 2214742 reaction equation
[C:1](Cl)(=[O:5])[CH2:2][CH2:3][CH3:4].[Br:7][C:8]1[CH:9]=[C:10]2[C:16](N)=[N:15][NH:14][C:11]2=[N:12][CH:13]=1.[N:18]1C=CC=CC=1>>[Br:7][C:8]1[CH:9]=[C:10]2[C:16]([CH:2]([CH2:3][CH3:4])[C:1]([NH2:18])=[O:5])=[N:15][NH:14][C:11]2=[N:12][CH:13]=1

Participants

4

Reactant 3

HCID 1049PyridineHCID 8855Butyryl chlorideHCID 178509224HCID 178509224, compound

Product 1

HCID 178449913HCID 178449913, compound

Procedure

Butyryl chloride (2.1 ml, 20.7 mmol) was added to a stirred solution of 5-bromo-1H-pyrazolo[3,4-b]pyridin-3-ylamine (4.0 g, 18.8 mmol) in pyridine (50 ml). The solution was heated at reflux for 12 hours then concentrated in vacuo. Addition of water afforded a solid which was filtered and dried to afford the title compound.

Workup

  1. temperatureThe solution was heated
  2. temperatureat reflux for 12 hours
  3. concentrationthen concentrated in vacuo
  4. additionAddition of water
  5. customafforded a solid which
  6. filtrationwas filtered
  7. customdried

Sources & evidence

ORD record
ord-c77980083628401b9c00b139d7d2ec63
Source dataset
uspto-grants-2006_09
Patent number
US07109199B2

Reaction notes

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