Hydrazinium chloride → HCID 178468624, compound

HRID 2214748Notes

Reaction equation

HRID 2214748 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9](=O)[CH2:10][C:11](O)([C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:12](OCC)=[O:13].Cl.[NH2:25][NH2:26]>C(O)C>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[N:26]=[N:25][C:12]([OH:13])=[C:11]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:10]=1

Participants

4

Reactant 2

HCID 115031Hydrazinium chlorideHCID 21948264Diethyl 2-[2-(2,3-difluorophenyl)-2-oxoethyl]-2-hydroxymalonate

Product 1

HCID 178468624HCID 178468624, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Diethyl 2-[2-(2,3-difluorophenyl)-2-oxoethyl]-2-hydroxymalonate (18.50 g, 56.1 mmol) and hydrazine monohydrochloride (4.03 g, 58.8 mmol) were stirred at reflux in ethanol (300 mL) for 96 h, and then evaporated to dryness to afford the title compound as a solid.

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-cdc60d1b2bbc4c56998918f30569d2e0
Source dataset
uspto-grants-2006_09
Patent number
US07109199B2

Reaction notes

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