反应详情

温度

90 °C

3-(2-Bromo-2-[1,2,4]triazol-1-yl-acetyl)-benzonitrile hydrobromide (500 mg, 1.34 mmol) is dissolved in ethanol (5 ml). (6-Methyl-pyridin-2-yl)-thiourea (208 mg, 1.34 mmol) is added and the reaction heated to 90° C. for 2 hours. The precipitate is collected and washed with ethanol twice. The solid is suspended in water and basified with concentrated ammonium hydroxide and the resulting precipitate collected and washed with water to give the title compound after drying. Mass Spec (APCI+) 360.0, m.p. 236–237° C.

1. customThe precipitate is collected
2. washwashed with ethanol twice
3. customthe resulting precipitate collected
4. washwashed with water