3,5-Dimethylaniline → HCID 9879089, compound

Participants

Reaction Steps

A solution of 4-(4-cyano-1H-pyrazol-5-yl)-2-(methylsulfinyl)pyrimidine (4-4, 155 mg, 0.66 mmol) and 3,5-dimethylaniline(3 mL, excess) was heated at 90° C. for 20 hours. The reaction was purified by flash chromatography. Elution with CH2Cl2 to 4% EtOAc/CH2Cl2 gave 4-(4-cyano-1H-pyrazol-5-yl)-2-[(3,5-dimethylphenyl)amino]pyrimidine (4-5) as a solid. 1H NMR (500 MHz, CDCl3) δ 9.00 (s, 1H), 8.63 (dd, 1H, J=5 Hz), 7.50 (dd, 1H, J=5 Hz), 7.31 (br s, 2H), 7.21 (br s, 1H), 6.74 (br s, 1H), 2.35 (s, 6H).

Provenance & Evidence