HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 15337738, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine | HCID 838363 | — |
| Reactant | α-Hydroxy-β-methoxy-β-phenylbenzenepropanenitrile | HCID 21927795 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 15337738 | HCID 15337738 | — |
Reaction Steps
7.3 g (28.8 mmol) of 2-hydroxy-3-methoxy-3,3-diphenylpropionitrile were dissolved in 90 ml of DMF, and 4 g (28.8 mmol) of K2CO3 and 6.3 g (28 mmol) of 2-methanesulfonyl-4,6-dimethoxypyrimidine were added. The mixture was stirred at room temperature for about 12 h, then poured into water and extracted with ethyl acetate. The combined organic phases were washed again with H2O, dried and concentrated. The residue obtained in this way was then purified by chromatography on silica gel (n-hepane/ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07109205B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-f91337a1c2b24bd9918fed12c6152acb |
| Source note | uspto-grants-2006_09 |