Sodium → HCID 86588354, compound

Participants

Reaction Steps

540 mg (467 μmol) of compound 23 was dissolved in 5 ml of a methanol/dichloromethane 1/1 solvent mixture. Sodium (cat.) was then added to the mixture. After 1 hour at ambient temperature, the solution was neutralized with Amberlite resin IR 120 (H+). This was filtered and concentrated under vacuum. Chromatography of the crude product (elution: cyclohexane/ethyl acetate=2.75/1) yielded 442 mg (yield=90%) of product 24 in the form of a colorless oil.

Provenance & Evidence