Hydrochloric Acid → 1-{[4-Ethoxycarbonylamino-1-(2-methyl-4-pyridyl)-4-piperidinyl]methyl}-2-piperazinone Hydrochloride

HRID 2214815Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2214815
[ClH:1].C(OC([N:12]1[CH2:17][CH2:16][N:15]([CH2:18][C:19]2([NH:32][C:33]([O:35][CH2:36][CH3:37])=[O:34])[CH2:24][CH2:23][N:22]([C:25]3[CH:30]=[CH:29][N:28]=[C:27]([CH3:31])[CH:26]=3)[CH2:21][CH2:20]2)[C:14](=[O:38])[CH2:13]1)=O)C1C=CC=CC=1>C(OCC)(=O)C.C(O)C.[C].[Pd]>[ClH:1].[CH2:36]([O:35][C:33]([NH:32][C:19]1([CH2:18][N:15]2[CH2:16][CH2:17][NH:12][CH2:13][C:14]2=[O:38])[CH2:20][CH2:21][N:22]([C:25]2[CH:30]=[CH:29][N:28]=[C:27]([CH3:31])[CH:26]=2)[CH2:23][CH2:24]1)=[O:34])[CH3:37]

Komponenten

6

Edukt 2

HCID 313Hydrochloric AcidHCID 219483344-Benzyloxycarbonyl-1-{[4-ethoxycarbonylamino-1-(2-methyl-4-pyridyl)-4-piperidiny]methyl}-2-piperazinone

Produkt 1

HCID 219483121-{[4-Ethoxycarbonylamino-1-(2-methyl-4-pyridyl)-4-piperidinyl]methyl}-2-piperazinone Hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A 4N hydrochloric acid solution in ethyl acetate (0.7 ml) and 10% palladium carbon (500 mg) were added to a solution of 4-benzyloxycarbonyl-1-{[4-ethoxycarbonylamino-1-(2-methyl-4-pyridyl)-4-piperidiny]methyl}-2-piperazinone (1.3 g) in ethanol (50 ml), and the mixture was stirred at room temperature for 15 hours under a nitrogen atmosphere. After the catalyst was removed, the solvent was distilled off to obtain the colorless amorphous title compound (1.15 g).

Aufarbeitung

  1. customAfter the catalyst was removed
  2. distillationthe solvent was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-8343bc83656e49de9df0f978d4087a83
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07109200B2

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