HCID 21948278, compound → HCID 21948286, compound

HRID 2214816Notes

Reaction equation

HRID 2214816 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][N:14]([CH2:17][C:18]2([NH:31][C:32]([O:34][CH2:35][CH3:36])=[O:33])[CH2:23][CH2:22][N:21]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:20][CH2:19]2)[C:13](=[O:37])[CH2:12]1)=O)C1C=CC=CC=1>C(O)C.[C].[Pd]>[C:27]([O:26][C:24]([N:21]1[CH2:20][CH2:19][C:18]([CH2:17][N:14]2[CH2:15][CH2:16][NH:11][CH2:12][C:13]2=[O:37])([NH:31][C:32]([O:34][CH2:35][CH3:36])=[O:33])[CH2:23][CH2:22]1)=[O:25])([CH3:28])([CH3:29])[CH3:30]

Participants

4

Reactant 1

HCID 21948278HCID 21948278, compound

Product 1

HCID 21948286HCID 21948286, compoundYield 110%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

10% Palladium carbon (600 mg) was added to a solution of 4-benzyloxycarbonyl-1-{[1-(tert-butoxycarbonyl)-4-ethoxycarbonylamino-4-piperidinyl]methyl}-2-piperazinone (1.79 g) in ethanol (50 ml), and the mixture was stirred at room temperature for 15 hours under a nitrogen atmosphere. After the catalyst was filtered, the solvent was distilled off to obtain the colorless amorphous title compound (1.46 g).

Workup

  1. filtrationAfter the catalyst was filtered
  2. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-8a682584e58c473198b4254742e6c32b
Source dataset
uspto-grants-2006_09
Patent number
US07109200B2

Reaction notes

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