Hydrogen chloride-ethyl acetate → HCID 69551091, compound

Participants

Reaction Steps

Ethyl 4-[[4-[(6-bromo-2-naphthyl)sulfonyl]-2-oxo-1-piperazinyl]methyl]-1-(4-pyridinyl)-4-piperidinylcarbamate (2.0 g) obtained in Example 17 was suspended in ethanol (20 ml), and 4N hydrochloric acid/ethyl acetate (1.2 ml) was added thereto at room temperature, followed by concentration under reduced pressure. The residue was dissolved in ethanol (8 ml), and ethyl acetate (50 ml) and diethyl ether (50 ml) were added. The resulting powders were collected to obtain the title compound (1.82 g) as colorless powders.

Provenance & Evidence