Water → 2-Amino-4-[4-(2-methoxyethoxy)phenyl]-6-[(2-methyl-1,3-thiazol-4-yl)methylsulphanyl]pyridine-3,5-dicarbonitrile

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Reaction Steps

100 mg (0.31 mmol) of 2-amino-4-[4-(2-methoxyethoxy)phenyl]-6-sulphanyl-pyridine-3,5-dicarbonitrile are dissolved in 1 ml of DMF. 103 mg (1.23 mmol) of sodium bicarbonate and 90.5 mg (0.61 mmol) of 4-chloromethyl-2-methyl-1,3-thiazole are then added. The suspension is shaken at RT overnight, and water is added. The precipitate is filtered off with suction and dried at 40° C. under reduced pressure. This gives 88.8 mg (66.2% of theory) of product.

Provenance & Evidence