Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → HCID 69590831, compound

Participants

Reaction Conditions

Reaction Steps

Mixture of compound 5F (130 mg, 0.3 mmol) and methyl (triphenylphosphoranylidene) acetate (110 mg, 0.33 mmol) in CDCl3 (15 mL) was heated to 60° C. for 2 h. After the reaction mixture was cooled to RT, ether (100 mL) was added and the mixture was passed through a short silica gel column eluted with ether. Solvent was removed to afford compound 5G as an off-white solid (95 mg, 65%). MS: 494 (M+1)+

Provenance & Evidence