Hydrochloric Acid → HCID 178527343, compound

Participants

Reaction Steps

1 M NaOH solution (0.63 mmol, 1.0 eq) is added to a stirred solution of 2,4-dichloro-N-[1-(2-cyano-ethyl)-1H-tetrazol-5-ylmethyl]-N-[2-(indan-5-yloxy)-ethyl]benzene sulfonamide (0.325 g, 1 eq.) in tetrahydrofuran (3 ml) at room temperature and the reaction mixture stirred overnight. The reaction mixture is acidified with 1 M HCl solution to pH 3, and then extracted with EtOAc (20 ml). The organic extract is washed with 1 M HCl solution (2×5 ml), and then with brine (1×10 ml), dried over MgSO4, and concentrated to give a crude solid (0.211 g), which is triturated with Et2O, filtered, washed with Et2O and dried under suction. The solid is purified by preparative HPLC to give pure 2,4-dichloro-N-[2-(indan-5-yloxy)-ethyl]-N-(1H-tetrazol-5-ylmethyl)benzene-sulfonamide.

Provenance & Evidence