反应详情

13.19 g of the above prepared (2-tert-butyl-5-methyl-oxazol-4-yl)-acetonitrile (74.0 mmol) was dissolved in 170 ml EtOH/water=1/1 and treated with 5 eq. of NaOH-pellets (14.8 g). Hydrolysis was allowed to proceed over night at 65° C. Pouring onto crashed ice/HCl, twofold extraction with AcOEt, washing with water, drying over sodium sulfate, followed by evaporation of the solvents, yielded 13.77 g of the title acid as waxy solid.

1. customHydrolysis
2. waitto proceed over night at 65° C
3. additionPouring
4. extractionice/HCl, twofold extraction with AcOEt
5. washwashing with water
6. dry with materialdrying over sodium sulfate
7. customfollowed by evaporation of the solvents
8. customyielded 13.77 g of the title acid as waxy solid