Hydrochloric Acid → HCID 69652629, compound

Participants

Reaction Steps

35.8 g (0.076 mol) of 1-(3-triphenylmethyloxy-2-(S)-methoxypropylthio)-2-methoxybenzene (XIII-1) and 150 ml of a solution of hydrochloric acid (2.5N) in ethanol are introduced into a round-bottomed flask kept under an inert atmosphere. The mixture is stirred at ambient temperature for 4 hours. The white precipitate formed is removed by filtration and the filtrate is concentrated under reduced pressure. The residue is purified by flash chromatography on silica gel (eluent: dichloromethane/ethyl acetate=90:10). 13.4 g (0.058 mol) of the title compound (XIV-1) are recovered in the form of an orange oil.

Provenance & Evidence