Sodium Thiosulfate → HCID 11160483, compound

Participants

Reaction Steps

4 g (0.017 mol) of 2-(S)-methoxy-3-(2-methoxyphenylthio)propan-1-ol (XIV-1), 100 ml of dichloromethane and 11.13 g (0.026 mol) of Dess-Martin reagent are introduced into a round-bottomed flask kept under an inert atmosphere. The mixture is stirred at ambient temperature for 3 hours. 190 ml of a saturated aqueous sodium thiosulfate solution are subsequently added, followed by 190 ml of a saturated aqueous sodium hydrogencarbonate solution, and the mixture is extracted with dichloromethane. The combined organic phases are washed with water and with brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The residue is purified by flash chromatography on silica gel (eluent: dichloromethane/ethyl acetate=95:5). 1.2 g (0.005 mol) of the title compound (IIa-1) are recovered in the form of a yellow oil.

Provenance & Evidence