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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2215372Generated: October 30, 2026

5-Aminoquinoline → HCID 10194889, compound

https://huagongshe.com/reaction/2215372

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-AminoquinolineHCID 11911—
Reactant2-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxiraneHCID 16099239—
SolventEthyl acetate hexaneHCID 21226206—
ProductHCID 10194889HCID 1019488927.7%

Reaction Steps

Analogously to Example 1, 200 mg (0.48 mmol) of 2-[2-(5-fluoro-2-methoxyphenyl)-2-methylpropyl]-2-(trifluoromethyl)oxirane is reacted with 99 mg (0.68 mmol) of 5-aminoquinoline. After chromatography on silica gel with hexane-ethyl acetate (0–70%), 58 mg of the product is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07109212B2
Source datasetuspto-grants-2006_09
ORD IDord-b18051feeaae45d1bb52fba208fbc34e
Source noteuspto-grants-2006_09